PMO-121 Osteopontin promotes natural killer T (NKT) cell accumulation in nonalcoholic steatohepatitis (NASH)

@article{Liaskou2012PMO121OP,
  title={PMO-121 Osteopontin promotes natural killer T (NKT) cell accumulation in nonalcoholic steatohepatitis (NASH)},
  author={E. Liaskou and L. Claridge and Rasha Younis and H. Shah and J. Shaw and Y. H. Oo and Z. Mi and P. Kuo and A. Canbay and D. Adams and A. Diehl and W. Syn},
  journal={Gut},
  year={2012},
  volume={61},
  pages={A122 - A122}
}
Introduction Progressive steatohepatitis is characterised by increased inflammatory cell infiltration. Osteopontin (OPN) is a cytokine intricately associated with immune-cell accumulation, and we reported that NKT cells accumulate to promote hepatic injury in NASH. We hypothesise that OPN promotes NASH progression by supporting NKT migration across hepatic sinusoidal endothelium. Methods Mice were fed chow or methionine-choline deficient (MCD) diet to induce NASH. After 4 weeks, mice were… Expand