PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1.

@article{Wu2014PML4FE,
  title={PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1.},
  author={Jie Wu and Li-Quan Zhou and Wei Yu and Zhi-guo Zhao and Xue-Min Xie and Wen-Tian Wang and Jian Xiong and Man Li and Zheng Feng Xue and Xing Wang and Peng Zhang and Bei-Bei Mao and De-long Hao and Xiang Lv and De-Pei Liu},
  journal={Blood},
  year={2014},
  volume={123 2},
  pages={261-70}
}
Promyelocytic leukemia protein (PML) has been implicated as a participant in multiple cellular processes including senescence, apoptosis, proliferation, and differentiation. Studies of PML function in hematopoietic differentiation previously focused principally on its myeloid activities and also indicated that PML is involved in erythroid colony formation. However, the exact role that PML plays in erythropoiesis is essentially unknown. In this report, we found that PML4, a specific PML isoform… CONTINUE READING
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