PML tumour suppression and beyond: therapeutic implications.

@article{Gamell2014PMLTS,
  title={PML tumour suppression and beyond: therapeutic implications.},
  author={Cristina Gamell and Piotr Jan Paul and Ygal Haupt and Sue Haupt},
  journal={FEBS letters},
  year={2014},
  volume={588 16},
  pages={
          2653-62
        }
}
  • Cristina Gamell, Piotr Jan Paul, +1 author Sue Haupt
  • Published in FEBS letters 2014
  • Biology, Medicine
  • Recognition of the tumour suppressive capacity of the Promyelocytic Leukemia protein (PML) has emerged beyond its identification through APL, to a broad spectrum of tumors. This ability has chiefly been linked to its role as a core component of dynamic structures termed PML Nuclear Bodies (PML-NBs). In response to a variety of stresses, key factors and their molecular modifiers are recruited to PML-NBs, where activating modifications are facilitated, leading to a cellular stress response. PML… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 12 CITATIONS

    Controlling senescence by PML and PML nuclear bodies

    VIEW 22 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    TRIM proteins in blood cancers

    VIEW 1 EXCERPT
    CITES RESULTS