PML nuclear bodies are general targets for inflammation and cell proliferation.

@article{Terris1995PMLNB,
  title={PML nuclear bodies are general targets for inflammation and cell proliferation.},
  author={Beno{\^i}t Terris and V{\'e}ronique Baldin and St{\'e}phanie Dubois and Claude Degott and J. F. Fl{\'e}jou and Dominique H{\'e}nin and Anne Dejean},
  journal={Cancer research},
  year={1995},
  volume={55 7},
  pages={1590-7}
}
Acute promyelocytic leukemia is associated with a t(15;17) translocation that generates a fusion product between PML and the retinoic acid receptor alpha. Recently, PML was shown to concentrate within subnuclear domains, referred to as nuclear bodies, that are disorganized in acute promyelocytic leukemia cells. This observation provided the first evidence that alteration of a nuclear structure may play a role in human pathogenesis. In an attempt to clarify the role of PML and, more generally… CONTINUE READING