PML is induced by oncogenic ras and promotes premature senescence.

@article{Ferbeyre2000PMLII,
  title={PML is induced by oncogenic ras and promotes premature senescence.},
  author={Gerardo Ferbeyre and Elisa de Stanchina and Emmanuelle Querido and Nicole Baptiste and Carol Prives and Scott W Lowe},
  journal={Genes & development},
  year={2000},
  volume={14 16},
  pages={
          2015-27
        }
}
Oncogenic ras provokes a senescent-like arrest in human diploid fibroblasts involving the Rb and p53 tumor suppressor pathways. To further characterize this response, we compared gene expression patterns between ras-arrested and quiescent IMR90 fibroblasts. One of the genes up-regulated during ras-induced arrest was promyelocytic leukemia (PML) protein, a potential tumor suppressor that encodes a component of nuclear structures known as promyelocytic oncogenic domains (PODs). PML levels… CONTINUE READING

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