PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein

Abstract

Nuclear foci containing the promyelocytic leukemia protein (PML bodies), which occur in most cells, play a role in tumor suppression. Here, we demonstrate that CHFR, a mitotic checkpoint protein frequently inactivated in human cancers, is a dynamic component of PML bodies. Intermolecular fluorescence resonance energy transfer analysis identified a distinct… (More)
DOI: 10.1038/nsmb837

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