PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

@inproceedings{Missiroli2016PMLAM,
  title={PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development},
  author={Sonia Missiroli and Massimo Bonora and Simone Patergnani and Federica Poletti and Mariasole Perrone and Roberta Gaf{\'a} and E. J. Magri and Andrea Raimondi and Giovanni Lanza and Carlo Tacchetti and Guido Kroemer and Pier Paolo Pandolfi and Paolo Pinton and Carlotta Giorgi},
  booktitle={Cell reports},
  year={2016}
}
The precise molecular mechanisms that coordinate apoptosis and autophagy in cancer remain to be determined. Here, we provide evidence that the tumor suppressor promyelocytic leukemia protein (PML) controls autophagosome formation at mitochondria-associated membranes (MAMs) and, thus, autophagy induction. Our in vitro and in vivo results demonstrate how PML functions as a repressor of autophagy. PML loss promotes tumor development, providing a growth advantage to tumor cells that use autophagy… CONTINUE READING
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