PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.

@article{Shima2008PMLAT,
  title={PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.},
  author={Yutaka Shima and Takito Shima and Tomoki Chiba and Tatsuro Irimura and Pier Paolo Pandolfi and Issay Kitabayashi},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 23},
  pages={7126-38}
}
PML, a nuclear protein, interacts with several transcription factors and their coactivators, such as HIPK2 and p300, resulting in the activation of transcription. Although PML is thought to achieve transcription activation by stabilizing the transcription factor complex, little is known about the underlying molecular mechanism. To clarify the role of PML in transcription regulation, we purified the PML complex and identified Fbxo3 (Fbx3), Skp1, and Cullin1 as novel components of this complex… CONTINUE READING