PML Nuclear Body Component Sp140 Is a Novel Autoantigen in Primary Biliary Cirrhosis

@article{Granito2010PMLNB,
  title={PML Nuclear Body Component Sp140 Is a Novel Autoantigen in Primary Biliary Cirrhosis},
  author={A Granito and Wei-hong Yang and Luigi Muratori and Mark Jyn-Huey Lim and Ayako Nakajima and Silvia Ferri and Georgios M Pappas and Chiara Quarneti and Francesco Bianco Bianchi and Donald B Bloch and Paolo Muratori},
  journal={The American Journal of Gastroenterology},
  year={2010},
  volume={105},
  pages={125-131}
}
OBJECTIVES:Some patients with primary biliary cirrhosis (PBC) have antinuclear antibodies (ANAs). These ANAs include the “multiple nuclear dots” (MND) staining pattern, targeting promyelocytic leukemia protein (PML) nuclear body (NB) components, such as “speckled 100-kD” protein (Sp100) and PML. A new PML NB protein, designated as Sp140, was identified… CONTINUE READING