PMEL: a pigment cell-specific model for functional amyloid formation.

  title={PMEL: a pigment cell-specific model for functional amyloid formation.},
  author={Brenda Watt and Guillaume van Niel and Graça Raposo and Michael S Marks},
  journal={Pigment cell & melanoma research},
  volume={26 3},
PMEL is a pigment cell-specific protein responsible for the formation of fibrillar sheets within the pigment organelle, the melanosome. The fibrillar sheets serve as a template upon which melanins polymerize as they are synthesized. The PMEL fibrils are required for optimal pigment cell function, as animals that either lack PMEL expression or express mutant PMEL variants show varying degrees of hypopigmentation and pigment cell inviability. The PMEL fibrils have biophysical properties of… CONTINUE READING
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