PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.

@article{Puustinen2009PME1PE,
  title={PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.},
  author={Pietri Puustinen and Melissa R Junttila and Sari Vanhatupa and Anna A. Sablina and Melissa E Hector and Kaisa J. Teittinen and Olayinka Raheem and Kirsi Ketola and Shujun Lin and Juergen Kast and Hannu Kalervo Haapasalo and William C. Hahn and Jukka Westermarck},
  journal={Cancer research},
  year={2009},
  volume={69 7},
  pages={2870-7}
}
Extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase pathway activity is regulated by the antagonist function of activating kinases and inactivating protein phosphatases. Sustained ERK pathway activity is commonly observed in human malignancies; however, the mechanisms by which the pathway is protected from phosphatase-mediated inactivation in the tumor tissue remain obscure. Here, we show that methylesterase PME-1-mediated inhibition of the protein phosphatase 2A… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Gene signature of the post-Chernobyl papillary thyroid cancer

European Journal of Nuclear Medicine and Molecular Imaging • 2015
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2008
View 2 Excerpts

CIP2A Inhibits PP2A inHumanMalignancies

MR Junttila, P Puustinen, M Niemela
Cell • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…