PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer.

@article{Vanhouten2010PMCA2RA,
  title={PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer.},
  author={Joshua N Vanhouten and Catherine Malone Sullivan and Caroline Bazinet and Tom Ryoo and Robert Camp and David L. Rimm and Gina G. Chung and John J. Wysolmerski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 25},
  pages={11405-10}
}
After lactation, weaning causes mammary epithelial cell (MEC) apoptosis. MECs express the plasma membrane calcium-ATPase 2 (PMCA2), which transports calcium across the apical surface of the cells into milk. Here we show that PMCA2 is down-regulated early in mammary involution associated with changes in MEC shape. We demonstrate that loss of PMCA2 expression raises intracellular calcium levels and sensitizes MECs to apoptosis. In contrast, overexpression of PMCA2 in T47D breast cancer cells… CONTINUE READING
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