PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration.

@article{Mowla2011PMAinducedUO,
  title={PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration.},
  author={Shaheen Mowla and Romaney Pinnock and Virna D. Leaner and C. R. Goding and Sharon Prince},
  journal={The Biochemical journal},
  year={2011},
  volume={433 1},
  pages={
          145-53
        }
}
The T-box transcription factor TBX3 provides an important link between embryonic development and cancer. TBX3 mediates limb, mammary gland and heart development and, in humans, mutations resulting in haplo-insufficiency of TBX3 lead to ulnar-mammary syndrome. Importantly, the de-regulation of TBX3 gene expression has been linked to several cancers, where it acts to suppress senescence and promotes proliferation and tumour invasion. Despite the negative impact of de-regulated TBX3 expression as… CONTINUE READING
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