PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling.

@article{Desai2016PMAAC,
  title={PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling.},
  author={Jyaysi Desai and Santhosh V. R. Kumar and Shrikant R Mulay and Lukas A Konrad and Simone Romoli and Christine Schauer and Martin Herrmann and Rostyslav Bilyy and Susanna Mueller and Bastian Popper and Daigo Nakazawa and Marc Weidenbusch and Dana Thomasova and Stefan Krautwald and Andreas Linkermann and Hans-Joachim Anders},
  journal={European journal of immunology},
  year={2016},
  volume={46 1},
  pages={223-9}
}
Neutrophil extracellular trap (NET) formation contributes to gout, autoimmune vasculitis, thrombosis, and atherosclerosis. The outside-in signaling pathway triggering NET formation is unknown. Here, we show that the receptor-interacting protein kinase (RIPK)-1-stabilizers necrostatin-1 or necrostatin-1s and the mixed lineage kinase domain-like (MLKL)-inhibitor necrosulfonamide prevent monosodium urate (MSU) crystal- or PMA-induced NET formation in human and mouse neutrophils. These compounds do… CONTINUE READING
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