PM2.5 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women

  title={PM2.5 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women},
  author={Diana Younan and Xinhui Wang and Ramon Casanova and Ryan T. Barnard and Sarah A. Gaussoin and Santiago Saldana and Andrew J. Petkus and Daniel P. Beavers and Susan M. Resnick and JoAnn E. Manson and Marc L. Serre and William Vizuete and Victor W. Henderson and Bonnie C. Sachs and Joel Salinas and Margaret Gatz and Mark A. Espeland and Helena Chui and Sally A. Shumaker and Stephen R. Rapp and Jiu Chiuan Chen},
  pages={e1190 - e1201}
Objective To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5 µm) contributes to progressive brain atrophy predictive of Alzheimer disease (AD) using a community-dwelling cohort of women (age 70–89 years) with up to 2 brain MRI scans (MRI-1, 2005–2006; MRI-2, 2010–2011). Methods AD pattern similarity (AD-PS) scores, developed by supervised machine learning and validated with MRI data from the Alzheimer’s Disease Neuroimaging Initiative, were used… 

Figures and Tables from this paper

Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?

Machine learning methods have been applied to estimate measures of brain aging from neuroimages. However, only rarely have these measures been examined in the context of biologic age. Here, we

Racial/Ethnic Disparities in Alzheimer's Disease Risk: Role of Exposure to Ambient Fine Particles.

PM2.5 may contribute to racial/ethnic disparities in AD risk and its associated increase inAD risk was stronger amongst Black women than in White women.

Associations Between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women.

Exposure to PM2.5 and NO2 are associated with patterns of cognitive performance characterized by worse verbal episodic memory relative to performance in other domains, according to latent profile structural equation models.

Long-term exposure to low-level air pollution, genetic susceptibility and risk of dementia.

The risk of dementia associated with a combination of air pollutants and high genetic susceptibility was greater than the addition of the risk associated with each individual factor, indicating significant interactions on an additive scale.

Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study

It is found that greater improvement in long-term AQ in late life associated with slower cognitive declines in older women strengthens the epidemologic evidence of aging, and the main limitations of this study include measurement error in exposure estimates, potential unmeasured confounding, and limited generalizability.

Association of improved air quality with lower dementia risk in older women

Long-term AQ improvement in late life was associated with lower dementia risk in older women and the observed associations did not substantially differ by age, education, geographic region, Apolipoprotein E e4 genotypes, or cardiovascular risk factors.

Comparing data‐driven and hypothesis‐driven MRI‐based predictors of cognitive impairment in individuals from the Atherosclerosis Risk in Communities (ARIC) study

Overall, the AD-PS scores were the stronger MRI-derived predictors of incident cognitive impairment in cognitively non-impaired individuals.

Integrating Environment and Aging Research: Opportunities for Synergy and Acceleration

This scoping review aims to highlight overlaps and gaps in existing knowledge and identify essential research initiatives to improve policy, reduce disparities, and enhance the quality of life for older individuals.

Physical Exercise in the Context of Air Pollution: An Emerging Research Topic

Physical exercise (PE) brings physiological benefits to human health; paradoxically, exposure to air pollution (AP) is harmful. Hence, the combined effects of AP and PE are interesting issues worth

Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality

Against this evolutionary background, an evolutionary approach facilitates the identification of practical solutions to the growing scandal of health disparities linked to inequality.



Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease.

The findings illustrate the continuum of PM2.5 neurotoxicity that contributes to early decline of immediate free recall/new learning at the preclinical stage, which is mediated by progressive atrophy of grey matter indicative of increased Alzheimer's disease risk, independent of cerebrovascular damage.

A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women

This is the first neuroimaging study reporting associations between air pollution exposure and smaller volumes of cortical GM and white matter in older women, and support the hypothesized synaptic neurotoxicity of airborne particles.

Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan.

Long-term exposure to O3 and PM2.5 above the current US EPA standards are associated with increased the risk of AD, according to the adjusted HR for AD.

Long-Term Exposure to Fine Particulate Matter, Residential Proximity to Major Roads and Measures of Brain Structure

Exposure to elevated levels of PM2.5 was associated with smaller total cerebral brain volume, a marker of age-associated brain atrophy, and with higher odds of covert brain infarcts, suggesting that air pollution is associated with insidious effects on structural brain aging even in dementia- and stroke-free persons.

Long-term PM2.5 Exposure and Neurological Hospital Admissions in the Northeastern United States

This is the first study to examine the relationship between long-term exposure to PM2.5 and time to first hospitalization for common neurodegenerative diseases and found strong evidence of association for all three outcomes.

Fine Particulate Matter, Residential Proximity to Major Roads, and Markers of Small Vessel Disease in a Memory Study Population.

There was no pattern of association between residential proximity to major roads or 2003 average PM2.5 and greater burden of small vessel disease or neurodegeneration in the Massachusetts Alzheimer's Disease Research Center Longitudinal Cohort.

Exposure to fine particulate matter and temporal dynamics of episodic memory and depressive symptoms in older women.

The data did not support depressive symptoms as the neuropsychological mediator of accelerated brain aging associated with PM2.5, and findings suggest that PM3.5 neurotoxicity may damage brain areas implicated in EM, followed by manifestation of depressive symptoms.

Alzheimer's Disease Risk Assessment Using Large-Scale Machine Learning Methods

New metrics to assess risk of Alzheimer's disease (AD) which are the conditional probabilities modeled by large-scale regularized logistic regression are introduced, called AD Pattern Similarity (AD-PS) scores.