PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti‐tumour activity

@article{Leal2010PM01183AN,
  title={PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti‐tumour activity},
  author={J. Leal and M. Mart{\'i}nez-D{\'i}ez and V. Garc{\'i}a-Hern{\'a}ndez and V. Moneo and A. Domingo and J. Bueren-Calabuig and A. Negri and F. Gago and M. J. Guill{\'e}n-Navarro and P. Avil{\'e}s and C. Cuevas and L. Garc{\'i}a-Fern{\'a}ndez and C. Galmarini},
  journal={British Journal of Pharmacology},
  year={2010},
  volume={161}
}
BACKGROUND AND PURPOSE PM01183 is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumours. In this study we have characterized the interactions of PM01183 with selected DNA molecules of defined sequence and its in vitro and in vivo cytotoxicity. 
Inhibitory effects of marine‐derived DNA‐binding anti‐tumour tetrahydroisoquinolines on the Fanconi anaemia pathway
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