PLP inhibits the activity of interphase centrosomes to ensure their proper segregation in stem cells

@inproceedings{Lerit2013PLPIT,
  title={PLP inhibits the activity of interphase centrosomes to ensure their proper segregation in stem cells},
  author={Dorothy A Lerit and Nasser M. Rusan},
  booktitle={The Journal of cell biology},
  year={2013}
}
Centrosomes determine the mitotic axis of asymmetrically dividing stem cells. Several studies have shown that the centrosomes of the Drosophila melanogaster central brain neural stem cells are themselves asymmetric, organizing varying levels of pericentriolar material and microtubules. This asymmetry produces one active and one inactive centrosome during interphase. We identify pericentrin-like protein (PLP) as a negative regulator of centrosome maturation and activity. We show that PLP is… CONTINUE READING
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