PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection.

@article{Noda2012PLOD2IU,
  title={PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection.},
  author={Takehiro Noda and Hirofumi Yamamoto and Ichiro Takemasa and Daisaku Yamada and Mamoru Uemura and Hiroshi Wada and Shogo Kobayashi and Shigeru Marubashi and Hidetoshi Eguchi and Masahiro Tanemura and Koji Umeshita and Yuichro Doki and Masaki Mori and Hiroaki Nagano},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2012},
  volume={32 1},
  pages={110-8}
}
BACKGROUND Under hypoxia, tumour cells undergo genetic and adaptive changes that allow their survival. Previously, we reported that high expression of hypoxia-inducible factor (HIF)-1 was a significant predictive factor for recurrence in hepatocellular carcinoma (HCC). Hypoxia also stimulates expression of procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD) genes via the HIF-1 pathway. AIMS The aim was to evaluate the relationship between hypoxia stress and expression of PLOD genes in HCC… CONTINUE READING

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