PLK4 phosphorylation of CP110 is required for efficient centriole assembly.


Centrioles are assembled during S phase and segregated into 2 daughter cells at the end of mitosis. The initiation of centriole assembly is regulated by polo-like kinase 4 (PLK4), the major serine/threonine kinase in centrioles. Despite its importance in centriole duplication, only a few substrates have been identified, and the detailed mechanism of PLK4… (More)
DOI: 10.1080/15384101.2017.1325555