PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer

@article{Shinmura2014PLK4OA,
  title={PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer},
  author={Kazuya Shinmura and Nobuya Kurabe and Masanori Goto and Hidetaka Yamada and Hiroko Natsume and Hiroyuki Konno and Haruhiko Sugimura},
  journal={Molecular Biology Reports},
  year={2014},
  volume={41},
  pages={6635-6644}
}
Polo-like kinase 4 (PLK4) is a centrosomal protein that is involved in the regulation of centrosome duplication. This study aimed to determine whether the genetic abnormality of PLK4 is involved in human gastric cancer. First, we examined the status of PLK4 mRNA expression in 7 gastric cancer cell lines and 48 primary gastric cancers using an RT-PCR analysis. The upregulation of PLK4 mRNA expression was detected in 57.1 % (4/7) of the gastric cancer cell lines, and a novel PLK4 variant with… CONTINUE READING

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