PLINK: a tool set for whole-genome association and population-based linkage analyses.

@article{Purcell2007PLINKAT,
  title={PLINK: a tool set for whole-genome association and population-based linkage analyses.},
  author={Shaun M Purcell and Benjamin M. Neale and Kathe Todd-Brown and Lori P Montross Thomas and Manuel A. R. Ferreira and David Bender and Julian B. Maller and Pamela Sklar and Paul I. W. de Bakker and Mark J. Daly and Pak Chung Sham},
  journal={American journal of human genetics},
  year={2007},
  volume={81 3},
  pages={
          559-75
        }
}
Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to researchers. Many existing genetic-analysis tools are not designed to handle such large data sets in a convenient manner and do not necessarily exploit the new opportunities that whole-genome data bring. To address these issues, we developed PLINK, an open-source C/C++ WGAS tool set. With PLINK, large data sets comprising hundreds of thousands of markers genotyped for thousands of individuals can… CONTINUE READING
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