PLIDA: cross-platform gene expression normalization using perturbed topic models

@article{Deshwar2014PLIDACG,
  title={PLIDA: cross-platform gene expression normalization using perturbed topic models},
  author={Amit G. Deshwar and Quaid Morris},
  journal={Bioinformatics},
  year={2014},
  volume={30 7},
  pages={956-61}
}
MOTIVATION Gene expression data are currently collected on a wide range of platforms. Differences between platforms make it challenging to combine and compare data collected on different platforms. We propose a new method of cross-platform normalization that uses topic models to summarize the expression patterns in each dataset before normalizing the topics learned from each dataset using per-gene multiplicative weights. RESULTS This method allows for cross-platform normalization even when… CONTINUE READING