PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.

@article{NDiaye2009PLICPO,
  title={PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.},
  author={Elsa-Noah N'Diaye and Kimberly K. Kajihara and Ivy Hsieh and Hiroshi Morisaki and Jayanta Debnath and Eric J. Brown},
  journal={EMBO reports},
  year={2009},
  volume={10 2},
  pages={173-9}
}
Ubiquilins (UBQLNs) are adaptor proteins thought to deliver ubiquitinated substrates to proteasomes. Here, we show a role for UBQLN in autophagy: enforced expression of UBQLN protects cells from starvation-induced death, whereas depletion of UBQLN renders cells more susceptible. The UBQLN protective effect requires the autophagy-related genes ATG5 and ATG7, two essential components of autophagy. The ubiquitin-associated domain of UBQLN mediates both its association with autophagosomes and its… CONTINUE READING