PLGA/PLA micro- and nanoparticle formulations serve as antigen depots and induce elevated humoral responses after immunization of Atlantic salmon (Salmo salar L.).

@article{Fredriksen2012PLGAPLAMA,
  title={PLGA/PLA micro- and nanoparticle formulations serve as antigen depots and induce elevated humoral responses after immunization of Atlantic salmon (Salmo salar L.).},
  author={B\orge Nilsen Fredriksen and Jostein Grip},
  journal={Vaccine},
  year={2012},
  volume={30 3},
  pages={656-67}
}
Novel vaccine delivery systems are highly needed to improve the salmon aquaculture industry. Although particles of biocompatible polymers such as poly(lactic-co-glycolic) acid (PLGA) have long been considered promising candidates for delivery of immunogenic compounds, few studies have addressed their use as vaccine carriers in Atlantic salmon (Salmo salar L.). Investigating their ability to retain/depot antigen and induce time and dosage dependent adaptive humoral responses to immunization, we… CONTINUE READING