PLETHORA proteins as dose-dependent master regulators of Arabidopsis root development

@article{Galinha2007PLETHORAPA,
  title={PLETHORA proteins as dose-dependent master regulators of Arabidopsis root development},
  author={Carla Galinha and Hugo F. Hofhuis and Marijn Luijten and Viola Willemsen and Ikram Blilou and Renze Heidstra and Ben Scheres},
  journal={Nature},
  year={2007},
  volume={449},
  pages={1053-1057}
}
Factors with a graded distribution can program fields of cells in a dose-dependent manner, but no evidence has hitherto surfaced for such mechanisms in plants. In the Arabidopsis thaliana root, two PLETHORA (PLT) genes encoding AP2-domain transcription factors have been shown to maintain the activity of stem cells. Here we show that a clade of four PLT homologues is necessary for root formation. Promoter activity and protein fusions of PLT homologues display gradient distributions with maxima… CONTINUE READING
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maintenance in Arabidopsis roots

  • V. A. Grieneisen, J. Xu, A. F. M. Marée, P. Hogeweg, B. Scheres
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