PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

Abstract

Excessive bone loss in arthritic diseases is mostly due to abnormal activation of the immune system leading to stimulation of osteoclasts. While phospholipase Cgamma (PLCgamma) isoforms are known modulators of T and B lymphocyte-mediated immune responses, we found that blockade of PLCgamma enzymatic activity also blocks early osteoclast development and… (More)

Topics

9 Figures and Tables

Slides referencing similar topics