PLASMA CHOLECYSTOKININ AND HEPATIC ENZYMES, CHOLESTEROL AND LIPOPROTEINS IN AMMONIUM PERFLUOROOCTANOATE PRODUCTION WORKERS

@article{Olsen2000PLASMACA,
  title={PLASMA CHOLECYSTOKININ AND HEPATIC ENZYMES, CHOLESTEROL AND LIPOPROTEINS IN AMMONIUM PERFLUOROOCTANOATE PRODUCTION WORKERS},
  author={Geary W. Olsen and Jean M. Burris and Michele M. Burlew and Jeffrey H. Mandel},
  journal={Drug and Chemical Toxicology},
  year={2000},
  volume={23},
  pages={603 - 620}
}
Ammonium perfluorooctanoate is a potent synthetic surfactant used in industrial applications. It rapidly dissociates in biologic media to perfluorooctanoate [CF3(CF2)6CO2−], which is the anion of perfluorooctanoic acid [PFOA, CF3(CF2)6COOH]. PFOA is a peroxisome proliferator known to increase the incidence of hepatic, pancreas and Leydig cell adenomas in rats. The pancreas acinar cell adenomas may be the consequence of a mild but sustained increase of cholecystokinin as a result of hepatic… 

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References

SHOWING 1-10 OF 49 REFERENCES

Serum perfluorooctanoic acid and hepatic enzymes, lipoproteins, and cholesterol: a study of occupationally exposed men.

The findings indicate that there is no significant clinical hepatic toxicity at the PFOA levels observed in this study and may modulate the previously described hepatic responses to obesity and xenobiotics.

An epidemiologic investigation of reproductive hormones in men with occupational exposure to perfluorooctanoic acid.

Results provide reasonable assurance that, in this production setting, there were no significant hormonal changes associated with PFOA at the serum levels measured, compared with those levels reported to cause effects in laboratory animal studies.

Mechanisms for the pancreatic oncogenic effects of the peroxisome proliferator Wyeth-14,643.

Chronic exposure to WY causes liver alterations such as cholestasis, which may increase plasma concentrations of CCK, and the absence of any early pancreas changes in the subchronic study is consistent with the in vitro data which demonstrated that WY is not a CCK(A) agonist or a trypsin inhibitor.

The Sex-Related Difference in Perfluorooctanoate Excretion in the Rat 1

Female rats are able to rapidly eliminate PFO in the urine by an active secretory mechanism which is inhibited by probenecid, which may explain the sex-related difference in PFO toxicity in which male rats are more susceptible to high doses than females.

Mortality among employees of a perfluorooctanoic acid production plant.

  • F. GillilandJ. Mandel
  • Medicine, Biology
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1993
PFOA may increase prostate cancer mortality by altering reproductive hormones in male workers because of its reported role in rodent hepatocarcinogenesis and human health effects associated with PFOA exposure.

Metabolic Handling of Perfluorooctanoic Acid in Rats

  • R. OphaugL. Singer
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1980
The available data suggest that perfluorooctanoic acid has been excreted intact or in possibly conjugated form after stomach intubation to female rats, and neither the ionic fluoride level in the serum nor the rate of ionic fluorine excretion in the urine was significantly altered.

Several nongenotoxic carcinogens uncouple mitochondrial oxidative phosphorylation.