PKR1 encodes an assembly factor for the yeast V-type ATPase.

@article{DavisKaplan2006PKR1EA,
  title={PKR1 encodes an assembly factor for the yeast V-type ATPase.},
  author={Sandra R Davis-Kaplan and Mark A Compton and Andrew R. Flannery and Diane M Ward and Jerry Kaplan and Tom H. Stevens and Laurie Ann Graham},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 42},
  pages={
          32025-35
        }
}
  • Sandra R Davis-Kaplan, Mark A Compton, +4 authors Laurie Ann Graham
  • Published in
    The Journal of biological…
    2006
  • Biology, Medicine
  • Deletion of the yeast gene PKR1 (YMR123W) results in an inability to grow on iron-limited medium. Pkr1p is localized to the membrane of the endoplasmic reticulum. Cells lacking Pkr1p show reduced levels of the V-ATPase subunit Vph1p due to increased turnover of the protein in mutant cells. Reduced levels of the V-ATPase lead to defective copper loading of Fet3p, a component of the high affinity iron transport system. Levels of Vph1p in cells lacking Pkr1p are similar to cells unable to assemble… CONTINUE READING

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