PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control.

@article{Kang2009PKRPK,
  title={PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control.},
  author={Ju-Il Kang and Shi-Nae Kwon and Se-Hoon Park and Yun Ki Kim and S Choi and Jungsuh P. Kim and Byung-Yoon Ahn},
  journal={Virus research},
  year={2009},
  volume={142 1-2},
  pages={51-6}
}
Hepatitis C virus (HCV) infection is currently treated with IFNalpha-based therapy but little is known how IFNalpha inhibits HCV replication. We show here that HCV JFH1 infection of human hepatoma Huh-7 cells leads to the activation of IFN-inducible protein kinase PKR and phosphorylation of the translation initiation factor eIF2alpha. Compared to a control cell HCV replication was significantly elevated in a PKR-knockdown cell, giving rise to a 10-fold higher viral titer, and was less sensitive… CONTINUE READING