PKR-dependent CHOP induction limits hyperoxia-induced lung injury.

@article{Lozon2011PKRdependentCI,
  title={PKR-dependent CHOP induction limits hyperoxia-induced lung injury.},
  author={Tricia I Lozon and Alison J. Eastman and Gustavo Matute-Bello and Peter Chen and Teal S. Hallstrand and William A Altemeier},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2011},
  volume={300 3},
  pages={L422-9}
}
Supplemental O(2) is commonly employed in patients with respiratory failure; however, hyperoxia is also a potential contributor to lung injury. In animal models, hyperoxia causes oxidative stress in the lungs, resulting in increased inflammation, edema, and permeability. We hypothesized that oxidative stress from prolonged hyperoxia leads to endoplasmic reticulum (ER) stress, resulting in activation of the unfolded protein response (UPR) and induction of CCAAT enhancer-binding protein… CONTINUE READING
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Production of immortalized distal respiratory L428

  • KA Wikenheiser, DK Vorbroker, +4 authors JA. Whitsett
  • CHOP AND HYPEROXIA AJP-Lung Cell Mol Physiol
  • 2011
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Chop deficient mice have augmented lung injury with hyperoxia (Abstract)

  • TI Lozon, WA Altemeier
  • Am J Respir Crit Care Med 179:
  • 2009

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