PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect.

@article{Dang2009PKM2TP,
  title={PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect.},
  author={Chi V. Dang},
  journal={Science signaling},
  year={2009},
  volume={2 97},
  pages={pe75}
}
New evidence suggests that the receptor tyrosine kinase FGFR1 (fibroblast growth factor receptor 1) directly phosphorylates pyruvate kinase M2 (PKM2), resulting in reduced conversion of phosphoenolpyruvate to pyruvate, which is further catabolized to lactate by lactate dehydrogenase A. Mutation of the critical tyrosine Tyr(105) to Phe rendered PKM2 more active but was associated with decreased cellular lactate production, increased oxygen consumption, and decreased hypoxic cell proliferation… CONTINUE READING

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