PKM2 regulates hepatocellular carcinoma cell epithelial-mesenchymal transition and migration upon EGFR activation.

@article{Fan2014PKM2RH,
  title={PKM2 regulates hepatocellular carcinoma cell epithelial-mesenchymal transition and migration upon EGFR activation.},
  author={Fang-tian Fan and Cun-si Shen and Li Tao and Chao Tian and Zhao-guo Liu and Zhi-jie Zhu and Yu-ping Liu and Chang-song Pei and Hong-yan Wu and Lei Zhang and Ai-yun Wang and Shi-zhong Zheng and Shi-le Huang and Yin Lu},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2014},
  volume={15 5},
  pages={
          1961-70
        }
}
Pyruvate kinase isozyme type M2(PKM2) was first found in hepatocellular carcinoma(HCC), and its expression has been thought to correlate with prognosis. A large number of studies have demonstrated that epithelial-mesenchymal transition (EMT) is a crucial event in hepatocellular carcinoma (HCC) and associated metastasis, resulting in enhanced malignancy of HCC. However, the roles of PKM2 in HCC EMT and metastasis remain largely unknown. The present study aimed to determine the effects of PKM2 in… CONTINUE READING

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