PKM2 and cancer: The function of PKM2 beyond glycolysis

  title={PKM2 and cancer: The function of PKM2 beyond glycolysis},
  author={Gaochao Dong and Qixing Mao and Wenjie Xia and Youtao Xu and Jie Wang and Ling Xu and Feng Jiang},
  booktitle={Oncology letters},
Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis to achieve the nutrient demands of cancer cell proliferation. In addition, the present study… CONTINUE READING
Highly Cited
This paper has 45 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 30 extracted citations

Oncogene-Driven Metabolic Alterations in Cancer

Biomolecules & therapeutics • 2018
View 6 Excerpts
Highly Influenced

Emerging roles of Myc in stem cell biology and novel tumor therapies

Journal of experimental & clinical cancer research : CR • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 61 references