PKM2 and cancer: The function of PKM2 beyond glycolysis

@inproceedings{Dong2016PKM2AC,
  title={PKM2 and cancer: The function of PKM2 beyond glycolysis},
  author={Gaochao Dong and Qixing Mao and Wenjie Xia and Youtao Xu and Jie Wang and Ling Xu and Feng Jiang},
  booktitle={Oncology letters},
  year={2016}
}
Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis to achieve the nutrient demands of cancer cell proliferation. In addition, the present study… CONTINUE READING
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