PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation.


BACKGROUND Deregulated Ras/Raf/mitogen-activated protein kinase and PI3 K/AKT/mTOR signaling pathways are significant in hepatocellular carcinoma proliferation (HCC). In this study we evaluated differences in the antiproliferative effect of dual PI3 K/Akt/mTOR and Ras/Raf/mitogen-activated protein kinase inhibition of non liver cancer stem cell lines (PLC… (More)
DOI: 10.1016/j.jss.2013.05.016