PKHD1 post‐transcriptionally modulated by miR‐365‐1 inhibits cell‐cell adhesion

  title={PKHD1 post‐transcriptionally modulated by miR‐365‐1 inhibits cell‐cell adhesion},
  author={J. Duan and H. Huang and Xiaoyan Lv and Honglian Wang and Ziwei Tang and Huan Sun and Qingwei Li and Jianzhong Ai and Ruizhi Tan and Yuhang Liu and Mianzhi Chen and Weiwei Duan and Yuquan Wei and Qin Zhou},
  journal={Cell Biochemistry and Function},
Autosomal recessive polycystic kidney disease (ARPKD) is a severe inherited disorder with an incidence of 1/20 000 live births. Mutations of PKHD1 (polycystic kidney and hepatic disease gene 1) gene were identified to be responsible for ARPKD. However, the underlying molecular mechanisms remain largely unknown. MicroRNAs (miRNAs) are an abundant class of small RNAs with global effect on gene expression. Up to 30% of human protein coding genes may be regulated by miRNAs. However, to date… Expand
Non-Coding RNAs in Hereditary Kidney Disorders
  • Julie Xia Zhou, Xiaogang Li
  • Medicine
  • International journal of molecular sciences
  • 2021
The Role of MicroRNAs in Kidney Disease
MicroRNAs and their applications in kidney diseases
MicroRNA‐365 Inhibits the Proliferation of Vascular Smooth Muscle Cells by Targeting Cyclin D1
Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases.
MicroRNAs in the pathogenesis of cystic kidney disease
MicroRNA expression profiling of cat and dog kidneys.
MicroRNAs and Polycystic Kidney Disease
The function of microRNAs in renal development and pathophysiology.


MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation
Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene.
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
Systematic validation of predicted microRNAs for cyclin D1
MicroRNA MiR-17 retards tissue growth and represses fibronectin expression
MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.
A role for microRNA in cystic liver and kidney diseases.
Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells.
MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
Role of 3’UTR Elements in the Regulation of the Cyclin D1 Proto-oncogene