PKD2 mutation in an Iranian autosomal dominant polycystic kidney disease family with misleading linkage analysis data☆


BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic renal disorder caused by mutation in 2 genes PKD1 and PKD2. Thus far, no mutation is identified in approximately 10% of ADPKD families, which can suggest further locus heterogeneity. Owing to the complexity of direct mutation detection, linkage analysis can initially… (More)
DOI: 10.1016/j.krcp.2016.02.003


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