PKD2 functions as an epidermal growth factor-activated plasma membrane channel.

@article{Ma2005PKD2FA,
  title={PKD2 functions as an epidermal growth factor-activated plasma membrane channel.},
  author={Rong Ma and Weiping Li and Dana R Rundle and Jin Kong and Hamid I. Akbarali and Leonidas Tsiokas},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 18},
  pages={8285-98}
}
PKD2, or polycystin 2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease, belongs to the transient receptor potential channel superfamily and has been shown to function as a nonselective cation channel in the plasma membrane. However, the mechanism of PKD2 activation remains elusive. We show that PKD2 overexpression increases epidermal growth factor (EGF)-induced inward currents in LLC-PK(1) kidney epithelial cells, while the knockdown of endogenous PKD2 by… CONTINUE READING
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