PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.


PKCζ has emerged as a pathologic mediator of endothelial cell dysfunction, based on its essential role in tumor necrosis factor α (TNFα)-mediated inflammation. In contrast, extracellular signal-regulated kinase 5 (ERK5) function is required for endothelial cell homeostasis as shown by activation of Krüppel-like factor 2 (KLF2), increased endothelial nitric… (More)
DOI: 10.1182/blood-2010-02-269134


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