PKCs: pernicious kinase culprits in acetaminophen pathogenesis.


A cetaminophen (APAP) overdose is the leading cause of acute liver failure in developed countries. APAP is metabolized in the liver by cytochromes P450 (CYPs) to N-acetyl-p-quinone imine (NAPQI), which depletes glutathione (GSH) and covalently modifies intracellular proteins. NAPQI-induced GSH depletion and protein binding in the mitochondria of hepatocytes… (More)
DOI: 10.1002/hep.26923


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@article{Ju2014PKCsPK, title={PKCs: pernicious kinase culprits in acetaminophen pathogenesis.}, author={Cynthia Ju and Robert A. Roth}, journal={Hepatology}, year={2014}, volume={59 4}, pages={1229-31} }