PKCh/b and CYLD Are Antagonistic Partners in the NFkB and NFAT Transactivation Pathways in Primary Mouse CD3 T Lymphocytes


In T cells PKCh mediates the activation of critical signals downstream of TCR/CD28 stimulation. We investigated the molecular mechanisms by which PKCh regulates NFkB transactivation by examining PKCh/b single and double knockout mice and observed a redundant involvement of PKCh and PKCb in this signaling pathway. Mechanistically, we define a PKCh-CYLD… (More)


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