PKCgamma contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain.


In previous studies we provided evidence that the gamma isoform of protein kinase C (PKCgamma) is an important contributor to the increased pain sensitivity that occurs after injury. Here we combined electrophysiological and behavioral approaches in wild-type and PKCgamma-null mice to compare the hyperexcitability of wide dynamic range neurons in lamina V… (More)


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