PKCepsilon upregulates voltage-dependent calcium channels in cultured astrocytes.

  title={PKCepsilon upregulates voltage-dependent calcium channels in cultured astrocytes.},
  author={Mar{\'i}a Jos{\'e} Grande Burgos and Mar{\'i}a Dolores Pastor and Jose Carlos Flores Gonzalez and Juan Ram{\'o}n Mart{\'i}nez-Gal{\'a}n and Cecilia F. Vaquero and Noelia Fradejas and Amparo Benavides and Jes{\'u}s Miguel Hern{\'a}ndez-Guijo and Pedro Tranque and Soledad Calvo},
  volume={55 14},
Astrocytes express voltage-gated calcium channels (VGCCs) that are upregulated in the context of the reactive astrogliosis occurring in several CNS pathologies. Moreover, the ability of selective calcium channel blockers to inhibit reactive astrogliosis has been revealed in a variety of experimental models. However, the functions and regulation of VGCC in astrocytes are still poorly understood. Interestingly, protein kinase C epsilon (PKCepsilon), one of the known regulators of VGCC in several… CONTINUE READING

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