PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells.

@article{Matassa2001PKCdeltaIR,
  title={PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells.},
  author={Angela A Matassa and Lee Carpenter and Trevor J Biden and Martin J Humphries and Mary E. Reyland},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 32},
  pages={29719-28}
}
We report here that the novel protein kinase C isoform, PKCdelta, is required at or prior to the level of the mitochondria for apoptosis induced by a diverse group of cell toxins. We have used adenoviral expression of a kinase-dead (KD) mutant of PKCdelta to explore the requirement for PKCdelta in the mitochondrial-dependent apoptotic pathway. Expression of PKCdeltaKD, but not PKCalphaKD, in salivary epithelial cells resulted in a dose-dependent inhibition of apoptosis induced by etoposide, UV… CONTINUE READING

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