PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells.

@article{Ryer2006PKCdeltaIN,
  title={PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells.},
  author={Evan J Ryer and Raymond Patrick Hom and Kenji Sakakibara and Keiichi I Nakayama and Keiko Nakayama and Peter L. Faries and Bo Yang Victor Liu and Kathleen C. Kent},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2006},
  volume={26 4},
  pages={780-6}
}
OBJECTIVE The purpose of these studies is to investigate the mechanism by which transforming growth factor (TGF)beta1 regulates the synthesis of the extracellular matrix protein fibronectin (FN). METHODS AND RESULTS TGFbeta1 elicited a time-dependent induction of FN protein and mRNA in A10 rat aortic smooth muscle cells (SMCs). Ectopic expression of Smad3… CONTINUE READING