PKCalpha regulates platelet granule secretion and thrombus formation in mice.

@article{Konopatskaya2009PKCalphaRP,
  title={PKCalpha regulates platelet granule secretion and thrombus formation in mice.},
  author={Olga Konopatskaya and Karen Gilio and Matthew T. Harper and Yan Zhao and Judith M E M Cosemans and Zubair A. Karim and Sidney W Whiteheart and Jeffery D Molkentin and Paul Verkade and Stephen P. Watson and Johan W. M. Heemskerk and Alastair W Poole},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 2},
  pages={399-407}
}
Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for regulating platelet activity, and platelets express several members of this family, including the classical isoforms PKCalpha and PKCbeta and novel isoforms PKCdelta and PKCtheta. Here, we used a genetic approach to definitively demonstrate the role played by PKCalpha in regulating thrombus formation and platelet function. Thrombus formation in… CONTINUE READING