PKCalpha regulates phosphorylation and enzymatic activity of cPLA2 in vitro and in activated human monocytes.

@article{Li2007PKCalphaRP,
  title={PKCalpha regulates phosphorylation and enzymatic activity of cPLA2 in vitro and in activated human monocytes.},
  author={Qing Li and Venkita Subbulakshmi and Claudine M. Oldfield and Rozina Aamir and Crystal M Weyman and Alan Wolfman and Martha K. Cathcart},
  journal={Cellular signalling},
  year={2007},
  volume={19 2},
  pages={359-66}
}
Phospholipases A(2) (PLA(2)) are potent regulators of the inflammatory response. We have observed that Group IV cPLA(2) activity is required for the production of superoxide anion (O(2)(-)) in human monocytes [Li Q., Cathcart M.K. J. Biol. Chem. 272 (4) (1997) 2404-2411.]. We have previously identified PKCalpha as a kinase pathway required for monocyte O(2)(-) production [Li Q., Cathcart M.K. J. Biol. Chem. 269 (26) (1994) 17508-17515.]. We therefore investigated the potential interaction… CONTINUE READING
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