PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes.

  title={PKC-zeta mediates insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes.},
  author={Gautam Kumar Bandyopadhyay and Mini P. Sajan and Yoshinori Kanoh and Mary L. Standaert and Michael J. Quon and Rene Lea-Currie and Anindita Sen and Robert V Farese},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={87 2},
Insulin-stimulated glucose transport is impaired in the early phases of type 2 diabetes mellitus. Studies in rodent cells suggest that atypical PKC (aPKC) isoforms (zeta, lamda, and iota) and PKB, and their upstream activators, PI3K and 3-phosphoinositide-dependent protein kinase-1 (PDK-1), play important roles in insulin-stimulated glucose transport. However, there is no information on requirements for aPKCs, PKB, or PDK-1 during insulin action in human cell types. Presently, by using… CONTINUE READING


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