PKC site mutations reveal differential modulation by insulin of NMDA receptors containing NR2A or NR2B subunits.

@article{Jones2005PKCSM,
  title={PKC site mutations reveal differential modulation by insulin of NMDA receptors containing NR2A or NR2B subunits.},
  author={Michelle Leigh Jones and John P. Leonard},
  journal={Journal of neurochemistry},
  year={2005},
  volume={92 6},
  pages={1431-8}
}
Insulin modulates N-methyl-d-aspartate (NMDA) receptors in the CNS and potentiates currents of recombinant NMDA receptors in a subunit-specific manner in Xenopus oocytes. Previously we identified two sites in the NR2B C-terminus as targets for direct phosphorylation by C-type protein kinases (PKCs). Mutating these sites reduced insulin potentiation of currents by one half, reflecting the PKC-mediated portion of the NR2B insulin effect. The PKC-proline rich tyrosine kinase (Pyk2)-Src family… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Roles of subunit phosphorylation in regulating glutamate receptor function.

European journal of pharmacology • 2014
View 5 Excerpts
Highly Influenced

Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning.

Proceedings of the National Academy of Sciences of the United States of America • 2016

Diversity in NMDA receptor composition: many regulators, many consequences.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry • 2013

Similar Papers

Loading similar papers…