PKC regulation of organic anion secretion in perfused S2 segments of rabbit proximal tubules.

@article{Shuprisha2000PKCRO,
  title={PKC regulation of organic anion secretion in perfused S2 segments of rabbit proximal tubules.},
  author={Apichai Shuprisha and Ronald M. Lynch and Stephen H. Wright and William H. Dantzler},
  journal={American journal of physiology. Renal physiology},
  year={2000},
  volume={278 1},
  pages={F104-9}
}
To examine the role of protein kinase C (PKC) in organic anion (OA) secretion, we used epifluorescence microscopy to study steady-state transepithelial secretion of 1 microM fluorescein (FL) by isolated perfused S2 segments of rabbit renal proximal tubules. Addition of 100 nM phorbol 12-myristate 13-acetate (PMA), a known PKC activator, to the bathing medium decreased steady-state secretion of FL by approximately 30% after 25 min. This inhibition was irreversible and, indeed, increased to… CONTINUE READING
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Protein kinase C regulation of organic anion transport in renal proximal tubule

  • D. S. Miller
  • Am. J. Physiol. Renal Physiol. 274:
  • 1998
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Cloning of the human kidney PAH transporter : narrow substrate specificity and regulation by protein kinase C

  • D. S Miller
  • Am . J . Physiol . Renal Physiol
  • 1999

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