PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance.

  title={PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance.},
  author={Meagan A. Jenkins and Stephen F Traynelis},
  volume={6 1},
AMPA receptors mediate fast excitatory synaptic transmission in the brain, and are dynamically regulated by phosphorylation of multiple residues within the C-terminal domain. CaMKII phosphorylates Ser831 within the AMPA receptor GluA1 subunit to increase single channel conductance, and biochemical studies show that PKC can also phosphorylate this residue. In light of the discovery of additional PKC phosphorylation sites within the GluA1 C-terminus, it remains unclear whether PKC phosphorylation… CONTINUE READING